Name：Takao Kinjo

• Position：Professor
• Research：Pathology, Cytology and Oncology
• Email：kinjotko (@u-ryukyu.ac.jp)

• 【Researcher bate base】http://kenkyushadb.lab.u-ryukyu.ac.jp/html/100000715_ja.html

• Tamanaha-Nakasone A, Uehara K, Tanabe Y, Ishikawa H, Yamakawa N, Toyoda Z, Kurima K, Kina S, Tsuneki M, Okubo Y, Yamaguchi S, Utsumi D, Takahashi K, Arakawa H, Arasaki A, Kinjo T. (2019)
  K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation.
  Sci Rep. 9: 6416. https://doi.org/10.1038/s41598-019-42763-0.
  
• Uehara K, Ikehara F, Shibuya R, Nakazato I, Oshiro M, Kiyuna M, Tanabe Y, Toyoda Z, Kurima K, Kina S, Hisaoka M, Kinjo T. (2018)
  Molecular signature of tumors with monoallelic 13q14 deletion: a case series of spindle cell lipoma and genetically-related tumors demonstrating a link between FOXO1 status and p38 MAPK pathway.
  Pathol Oncol Res. 24: 861-869. DOI: 10.1007/s12253-017-0303-6.
  
• Uehara K, Iwashita H, Tanabe Y, Kurima K, Oshiro M, Kina S, Ota A, Iwashita A, Kinjo T. (2017)
  Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes.
  Open Med (Wars)12:335-339. DOI: 10.1515/med-2017-0048.
  
• Uehara K, Ikehara F, Tanabe Y, Nakazato I, Oshiro M, Inamine M, Kinjo T. (2016)
  CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival.
  Diag Pathol 11: 16. doi:10.1186/s 13000-016-0468-4
  
• Arakaki K, Chinen K, Kamiya K, Tanabe Y, Tawata N, Ikehara F, Uehara K, Shimabukuro H, Kinjo T. (2014)
  Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report. Int J Clin Exp Pathol 7: 8972-8979.
  
• Shimabuku T, Tamanaha A, Kitamura B, Tanabe Y, Tawata N, Ikehara F, Arakaki K,
  Kinjo T. (2014)
  Dual expression of Epstein-Barr virus, latent membrane protein-1 and human papillomavirus-16 E6 transform primary mouse embryonic fibroblasts through NF-kB signaling.
  Int J Clin Exp Pathol. 7: 1920-1934.

Master

• Transformation capacity by dual infection of HPV and EBV.
• Comparison between K1 gene function of AIDS related KS and Okinawan classic KS.
• Transformation activity of HTLV-I Tax.
• Evasion of apoptosis on mouse embryonic stem cells by HTLV-I Tax.
• Evaluation of transformation activity in double-expression of low-risk HPV E6/E7 and EBV LMP-1.

Doctor

• Tamanaha-Nakasone A, Uehara K, Tanabe Y, Ishikawa H, Yamakawa N, Toyoda Z, Kurima K, Kina S, Tsuneki M, Okubo Y, Yamaguchi S, Utsumi D, Takahashi K, Arakawa H, Arasaki A, Kinjo T. (2019)
  K1 gene transformation activities in AIDS-related and classic type Kaposi’s sarcoma: Correlation with clinical presentation.
  Sci Rep. 9: 6416. https://doi.org/10.1038/s41598-019-42763-0.

Okinawa, subtropical islands in the southwestern part of Japan, has unique diseases, not found in mainland Japan. Especially, many viral infections are demonstrated in the tumors seen in Okinawa. Our research focuses on the relationship between tumors in Okinawa and viral infections to reveal oncogenesis induced by these infectious agents. We have published our scientific findings in international academic journals.